

Aries 6504 Pro BSI sCMOS Camera, 0.43 e⁻ RMS Read Noise, 297 fps
Aries 6504 ProDesign Tools
A sub-electron-noise sCMOS camera for quantitative low-light imaging at high frame rates.
The Aries 6504 Pro is built on the back-illuminated GSENSE6504BSI sensor (2048 × 2048, 6.5 µm pixels) and offers three readout modes. In Sensitive mode it reaches 0.43 e⁻ RMS read noise at 99 fps, low enough to resolve individual photoelectron peaks, while Speed mode delivers 297 fps at the full 4.2 MP with 0.8 e⁻ RMS. Dark current of 0.01 e⁻/pixel/s or less at −20 °C also supports long, quantitative exposures.
Key Features
- Sensitive mode: 0.43 e⁻ RMS read noise (0.36 e⁻ median) at 99 fps and 4.2 MP, with photon-number peaks clearly separated at about 2 e⁻/pixel
- Speed mode: 297 fps at full 4.2 MP resolution with 0.8 e⁻ RMS read noise
- Dynamic (HDR) mode: 170 fps at 4.2 MP with 16-bit output and 15 ke⁻ full well
- 95% peak QE at 450 nm across a 200–1100 nm spectral range
- Dark current ≤ 0.01 e⁻/pixel/s at −20 °C with liquid cooling; air cooling to −10 °C
- USB 3.2 Gen 2×2 and dual CXP-12 interfaces at the same frame rates, four SMA trigger connectors and timestamps
Typical Applications
- Super-resolution microscopy, including SIM
- Light-sheet microscopy
- Calcium and voltage imaging
- High-content imaging
- Bioluminescence imaging
- Quantum physics and astronomy research
Related Products
- Aries 1517 — Vacuum-Cooled BSI sCMOS Camera, 87 mm Diagonal, 15 µm Pixels
- Aries 16 LT — BSI sCMOS Camera, 16 µm Pixels, 0.9 e⁻ Read Noise
- Aries 6504 LT — Compact BSI sCMOS Camera, 0.8 e⁻ Read Noise, 100 fps
Browse all: sCMOS Cameras · Cameras
Model: Aries 6504 Pro · Acquisition software and drivers are supplied with the camera. Contact WaveQuanta for a quote and lead time.
| Sensor Type | BSI sCMOS |
| Sensor | GSENSE6504BSI |
| Color / Mono | Mono |
| Peak QE | 95% @ 450 nm |
| Spectral Range | 200–1100 nm |
| Resolution | 2048 × 2048 |
| Pixel Size | 6.5 µm × 6.5 µm |
| Effective Area | 13.3 mm × 13.3 mm |
| Array Diagonal | 18.8 mm |
| Full-Well Capacity | 15 ke⁻ (Dynamic mode) |
| Readout Noise | 0.43 e⁻ RMS (Sensitive mode); 0.8 e⁻ RMS (Speed mode) |
| Dynamic Range | 91 dB (Sensitive mode) |
| Frame Rate | 99 fps (Sensitive); 170 fps (Dynamic); 297 fps (Speed), all at 4.2 MP |
| Shutter Type | Rolling, global reset |
| Binning | 2 × 2, 4 × 4 |
| ROI | Supported |
| Cooling Method | Liquid, air |
| Cooling Temperature | Liquid: −20 °C @ 20 °C coolant; air: −10 °C @ 25 °C ambient |
| Dark Current | ≤ 0.01 e⁻/pixel/s @ −20 °C |
| DSNU / PRNU | 0.1 e⁻ (Dynamic mode) / 0.3% |
| Bit Depth | 12 bit, 16 bit |
| Data Interface | USB 3.2 Gen 2×2, CXP-12 × 2 |
| Trigger | Hardware, software; 4 × SMA; timestamp supported |
| Trigger Output | Readout End, Global Exposure, Exposure Start, Trigger Ready, First Row, Any Row, High, Low |
| Optical Interface | C-mount |
| Power Supply | DC 12 V |
| Power Consumption | 60 W |
| Dimensions | 80 mm × 80 mm × 108 mm (camera body only) |
| Weight | 950 g |
| Operating Environment | Working 0–40 °C, 20–80% RH, 0–3000 m; storage −20 to 60 °C, 20–80% RH |
| Software / SDK Support | Acquisition and analysis software; C / C++ SDK; Windows 10 / 11, Ubuntu 22.04 |






